Below you will find references to methodological papers written by our staff, underlying the tools used by Delta Phenomics. PDF copies are available on request.

PhenoMAP platform

Kuurman, W.W.; Visser de, L. (2005). Behavioral phenotyping: getting more information from video tracking data. Proceedings of Measuring Behavior 2005, 5th International Conference on Methods and Techniques in Behavioral Research (Wageningen, 30 August - 2 September 2005), 77-80.
 
Spruijt, B.; de Visser, L. (2006). Advanced behavioural screening: automated home cage ethology. Drug Discovery Today: Technologies, 3, 231-237.

Visser, L. de; Bos van den, R.; Spruijt, B.M. (2005). Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion. Behavioural Brain Research, 160, 382-388.
 
Visser, L. de; Bos van den, R.; Kuurman, W.W.; Kas, M.J.H.; Spruijt, B.M. (2006). Novel approach to the behavioural characteristics of inbred mice: automated home cage observations. Genes, Brain and Behavior, 5, 458-466.

Visser, L. de; Bos van den, R.; Stoker, A.; Kas, M.; Spruijt, B. (2007). Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice. Behavioural Brain Research, 177, 290-297.

Visser, L. de (2008). Home sweet home: Home cage testing for behavioural phenotyping of mice. Ph.D. Thesis, Utrecht University, 186 pp.

Video tracking, behavior recognition and analysis

Noldus, L.P.J.J.; Spink, A.J.; Tegelenbosch, R.A.J. (2001). EthoVision: a versatile video tracking system for automation of behavioral experiments.
Behavior Research Methods, Instruments & Computers, 33, 398-414.

Rousseau, J.B.I.; Lochem, P.B.A. van; Gispen, W.H.; Spruijt, B.M. (2000). Classification of rat behavior with an image-processing method and a neural network. Behavior Research Methods, Instruments & Computers, 32, 63-71.

Spink, A.J.; Tegelenbosch, R.A.J.; Buma, M.O.S.; Noldus, L.P.J.J. (2001). The EthoVision video tracking system: a tool for behavioral phenotyping of transgenic mice. Physiology & Behavior, 73, 731-744.

Spruijt, B.M. (1991) Progressive decline in social attention in aging rats: an informational-statistical method. Neurobiology of Aging, 13, 145-151.

Spruijt, B.M.; Gispen, W.H. (1983). Prolonged animal observation by use of digitized video displays. Pharmacology, Biochemistry & Behavior, 19, 765 769.

Spruijt, B.M.; Gispen, W.H. (1984). Behavioral sequences as an easily quantifiable parameter in experimental studies. Physiology & Behavior, 32, 707-710.

Spruijt, B.M.; Hol, T.; Rousseau, J. (1992). Approach, avoidance and contact behavior of individually recognized animals automatically quantified with an imaging technique. Physiology & Behavior, 51, 747-752.

Social stress model

Cornelisse, L.N.; van der Harst, J.E.; Lodder, J.C.; Baarendse, P.J.J.; Timmerman, A.J.; Mansvelder, H.D.; Spruijt, B.M.; Brussaard, A.B. (2008). Reduced 5-HT1A- and GABAB receptor function in dorsal raphé upon chronic fluoxetine treatment correlates with relief from symptoms of depression in rats. Journal of Neurophysiology, in press.

Van der Harst, J.E.; Baars, J.M.; Spruijt, B.M. (2005). Announced rewards counteract the impairment of anticipatory behaviour in socially stressed rats. Behavioural Brain Research, 161, 183-189.

Von Frijtag J.C.; Reijmers, L.G.J.E.; Van der Harst, J.E.; Leus, I.E.; Van den Bos, R.; Spruijt, B.M. (2000). Defeat followed by individual housing results in long-term impaired reward- en cognition-related behaviours in rats. Behavioural Brain Research, 117, 137-146.